What is BS EN ISO 6353-2:2021?

BS EN ISO 6353-2:2021 is a technical standard that provides guidelines for the determination of particle size distribution in powders. It specifies the optical microscope method and covers a wide range of particle sizes, from the sub-micrometer to millimeter scale.

Importance of Particle Size Distribution Analysis

Particle size distribution plays a crucial role in numerous industries, including pharmaceuticals, cosmetics, food processing, and manufacturing. The physical and chemical properties of powders are directly influenced by the size and shape of particles. Therefore, understanding and controlling particle size distribution is essential for ensuring product quality and performance.

An accurate analysis of particle size distribution enables manufacturers to optimize processes such as mixing, granulation, and milling. It allows them to determine the appropriate particle size range for better flowability, dissolution, and homogeneity of the final product. Furthermore, it aids in troubleshooting and identifying potential issues, such as agglomeration or segregation.

The Optical Microscope Method

The optical microscope method outlined in BS EN ISO 6353-2:2021 is widely used due to its simplicity and affordability. It involves preparing a sample of the powder on a glass slide and examining it under an optical microscope equipped with a calibrated eyepiece graticule.

During the analysis, the operator counts a representative number of particles within a specified area and records their sizes. The results are then statistically analyzed to obtain the particle size distribution of the powder sample. It is important to note that this method primarily measures particle sizes based on their two-dimensional projections.

Other Methods for Particle Size Analysis

While the optical microscope method is commonly employed, there are alternative techniques available for particle size distribution analysis. These include laser diffraction, dynamic light scattering, sedimentation, and image analysis.

Laser diffraction is a popular choice for its ability to measure a wide range of particle sizes quickly. It utilizes the principle of light scattering to calculate particle sizes based on the diffraction pattern produced when a laser beam interacts with particles suspended in a liquid or dispersed in air.

Dynamic light scattering, on the other hand, measures the Brownian motion of particles in suspension to determine their hydrodynamic radius. Sedimentation involves observing the settling velocity of particles in a liquid, which can then be used to calculate their sizes.

Image analysis techniques employ automated software algorithms to analyze images of particles captured using microscopy or other imaging methods. These algorithms can provide detailed information about particle shape and morphology in addition to size distribution.

In Conclusion

BS EN ISO 6353-2:2021 offers valuable guidelines for determining particle size distribution using the optical microscope method. While this method is widely used and accessible, alternative techniques such as laser diffraction, dynamic light scattering, sedimentation, and image analysis are also available for more specific requirements. Understanding and controlling particle size distribution is crucial for optimizing manufacturing processes and ensuring product quality in various industries.